Director’s Message
Welcome to the Oakland University William Beaumont School of Medicine Eye Research Center (OUWB-ERC) webpage! We invite you to explore the site to learn more about our faculty, members, ongoing research, programs and goals. Our mission is to conduct multidisciplinary basic and clinical research to understand the pathophysiology of eye diseases and discover new therapeutic targets to prevent and treat vision-threatening eye diseases. New therapies will improve the quality of life and eliminate the socioeconomic burden of eye diseases on our community. The overall goals of the new ERC are to foster interdisciplinary collaborative research and academic programs, enhance OU and OUWB competitiveness for extramural funded research, promote new areas of research including translational research and foster research training programs. The OUWB-ERC brings together several investigators from various departments, research institutes, laboratories and programs who share an interest in eye research to collaboratively investigate the pathophysiology of eye diseases and translate data to novel diagnostic and therapeutic approaches. Among these research programs is the well-established Oakland University Eye Research Institute ( ERI), OUWB Neuroscience program, the Department of Ophthalmology, Population Health Informatics and the OU Department of Biological Sciences. Our research laboratories provide an excellent environment for the training of undergraduate, medical and graduate students as well as postdoctoral fellows. In addition, we offer research opportunities for residents and fellows in Ophthalmology. The ERC has investigators who conduct full-time research that includes, but is not limited to diabetic retinopathy, retinopathy of prematurity, retinal degenerative diseases, age-related macular degeneration, blood-retinal and blood-brain barrier function, and bioinformatics. In addition to individual investigators' labs, the ERC has a core facility that contains all the necessary equipment for morphological, molecular, and functional studies. There are currently four modules: Microscopy, In vivo imaging, Functional Assessment, and Cell and Molecular Biology modules.
We hope this webpage introduces you to our faculty and their research programs. Feel free to contact any faculty member or me if you have further questions.
Mohamed Al-Shabrawey, MBBCH (M.D.), M.Sc., Ph.D.
Professor in the Department of Foundational Medical Studies
Professor in Eye Research Institute and V. Everett Kinsey Endowed Professor
Founding Director, Eye Research Center, OUWB
Director, Eye Research Institute, Oakland University
Contact Us
Kathy Wolosiewicz
Operations Coordinator
422 Dodge Hall
118 Library Drive
Rochester, Mich. 48309
Email: kw[email protected]
More than $4.7 million in new grantsR01EY033808-01A1-NIH National Eye Institute R15EY034305-01A1 NIH/National Eye Institute R41EY030807-01 – NIH/National Eye Institute Title: Natural history and AAV-mediated interventions for dominant negative and haploinsufficient mouse models of PRPH2-associated disease" American Heart Association Institutional Award for Undergraduate Student Training |
ERI, ERC represented at ARVO 2024The Eye Research Institute and OUWB Eye Research Center presented 13 posters during 2024 ARVO. The posters were presented by undergraduate, graduate students, medical students and postdoctoral fellows. Full story here. |
Summer Undergraduate Program in Eye Research (SUPER) held for undergradsEye Research concluded a 12-week summer research program for undergraduate students during which seven students worked on assigned research project under the mentorship of the ERC and ERI faculty members |
Risner joins ERC, ERIDr. Risner joined the Eye Research Center and Institute in September 2023. Full story here. |
Mitton serves as expert for CBSDr. Mitton served as an expert for a local news report leading up to April's solar eclipse. The clip can be found here. |
- Dopamine and dopamine neurons in normal and diseased retinas.
- Elucidating photoreceptor biology to understand (and combat) retinal degenerative diseases (RDDs).
- Molecular and cellular mechanisms of age-related macular degeneration e.g. Role of hyperhomocysteinemia.
- Molecular and cellular mechanisms of microvascular dysfunction (hyperpermeability and neovascularization) in diabetic retinopathy in particular role of bioactive lipids, homocysteine and bone morphogenetic proteins.
- New therapies for retinopathy of prematurity.
- Traumatic optic neuropathy.
Our Research Roots
Co-founder and first director of the ERI, Dr. V. Everett Kinsey was the recipient of the 1956 Albert Lasker Clinical Medical Research Award from the Lasker Foundation for his outstanding work as coordinator of the National Cooperative Study of Retrolental Fibroplasia.
With the help of 75 ophthalmologists and pediatricians in 18 hospitals, this study confirmed conclusively earlier observations that the incidence of blindness among premature babies increased with the duration of exposure to oxygen.
Previous research had eliminated other possible etiologic agents, such as virus infection, lack of hormones in the infant, exposure of the premature infant's eyes to light, lack of vitamin A in the mother, the administration of various vitamins and iron, blood transfusions and cow's milk. Dr. Kinsey, a biochemist, had participated in many of the studies on these possible agents.
Within a period of six months, data were accumulated through the cooperative study that would have taken a single hospital several years. Among babies weighing less than 1500 grams at birth, 25 percent of the infants receiving routine oxygen developed cicatricial retrolental fibroplasia, while only 6 percent of the infants on curtailed oxygen had the condition. The study showed that limiting the oxygen was without effect on survival.
In the United States alone, putting into effect the results of this coordinated research should prevent blindness in several hundred premature infants each year.
Mohamed Al-Shabrawey, Ph.D. V. Everett Kinsey Endowed Professor, Department of Foundational Medical Studies, OUWB Founding Director, Eye Research Center, OUWB Director, Eye Research Institute, Oakland University [email protected] |
Andrew F.X. Goldberg, Ph.D. Professor of Biomedical Sciences [email protected] |
Kenneth Mitton, Ph.D. |
Dao-Qi Zhang, Ph.D. |
Amany Tawfik, M.D., M.Sc. |
Michael Risner, Ph.D. |
Frank Giblin, Ph.D., Distinguished Professor Emeritus of Biomedical Sciences [email protected] |
Michael Riley, Ph.D. |
Barry Winkler, Ph.D. Professor Emeritus of Biomedical Sciences [email protected] |
Antonio Capone, Jr., M.D.After completing his Fellowship in 1991, Dr. Capone joined the faculty at Emory University, where he was a tenured Associate Professor of Ophthalmology and Director of Emory's Vitreoretinal Fellowship Training Program. He joined Associated Retinal Consultants in Royal Oak, MI in 2000. He is a board certified ophthalmologist whose special interests include pediatric vitreoretinal diseases, complicated retinal detachment, ocular oncology and macular disease. Dr. Capone is an internationally recognized clinician, surgeon and educator. He has authored or co-authored over 300 publications in peer-reviewed medical journals, book chapters, and publications from clinical trials. He is currently a Professor of Ophthalmology at Oakland University William Beaumont Hospital School of Medicine. He served as Co-President of ARC from 2015-2021, and currently serves as Chairman of the Medical Executive Board for EyeCare Partners and President of the Pediatric Retina Research Foundation. He has been dedicated to education throughout his career, has served as Director/Co-Director of the Associated Retinal Consultants Vitreoretinal Fellowship Training Program, and has trained many domestic and international thought leaders in adult and pediatric retinal diseases and surgery. Dr. Capone is a member of many professional organizations, including the American Academy of Ophthalmology, American College of Surgeons, American Society of Retina Specialists, Club Jules Gonin, Macula Society, Retina Society, Association for Research in Vision in Ophthalmology, and the International Society for Eye Research, and serves on the Executive Committee of the Retina Society. |
Tarek S. Hassan, M.D.Tarek S. Hassan, M.D. is Professor of Ophthalmology at Oakland University William Beaumont School of Medicine and Director of the Vitreoretinal Fellowship Training Program and Partner at Associated Retinal Consultants in Royal Oak, Michigan. He is the President of the Retina World Congress (RWC), President of the Retina Hall of Fame (RHOF), Past President of the American Society of Retina Specialists (ASRS), and Past President of the Foundation of the ASRS. He served 12 years on the Executive Committees of the ASRS and the Foundation of the ASRS and has been on the ASRS Board of Directors for 22 years. He was Program Chairman of two ASRS Annual Meetings and two Retina Subspecialty Day Meetings at the American Academy of Ophthalmology (AAO). He is a Founder and the current President of the Retina Fellows Forum, Club Vit, RWC, and RHOF. He has been an investigator in more than 150 national trials and has authored more than 230 peer-reviewed papers and 9 books and book chapters. He presently serves as Senior Associate Editor of the Journal of Vitreoretinal Diseases and as an editor of several other leading journals. He has given over 750 national and international podium presentations on numerous retinal topics. He has been awarded the AAO Achievement Award, ASRS Senior Honor Award, and AAO Senior Achievement Award, and was elected as an inaugural member of the RHOF. He has been honored to train 54 clinical and 25 international research vitreoretinal fellows in his active academic clinical practice. |
Alon Kahana, M.D., Ph.D.Dr. Kahana is a surgeon-scientist with a clinical focus on oculoplastic and orbital surgery. His basic and translational research interests over a 30-year academic career have ranged from epigenetics to embryogenesis to stem cells to cancer to inflammation. His current research focus areas are: (1) the role of nuclear receptor ligands as mediators of orbital inflammatory conditions, particularly thyroid eye disease; (2) the biology and treatment of cicatrizing conjunctival disorders (e.g. ocular cicatricial pemphigoid, Stevens Johnson Syndrome); and (3) basal cell carcinoma of the eyelids and orbit. Dr. Kahana completed his undergraduate studies in Biochemistry at Brandeis University, graduating Summa Cum Laude and with Phi Beta Kappa honors. Dr. Kahana received his M.D. (with Honors) as well as a Ph.D. in Molecular Genetics and Cell Biology from The University of Chicago Pritzker School of Medicine. He completed his residency in Ophthalmology and fellowship in Oculofacial Plastic and Reconstructive Surgery at the University of Wisconsin in Madison. In 2007, completed his undergraduate studies in Biochemistry at Brandeis University, graduating Summa Cum Laude and with Phi Beta Kappa honors. Dr. Kahana received his MD (with Honors) as well as a PhD in Molecular Genetics and Cell Biology from The University of Chicago Pritzker School of Medicine. He completed his residency in ophthalmology and a prestigious ASOPRS fellowship in oculofacial plastic and reconstructive surgery at the University of Wisconsin under the preceptorship of Dr. Mark Lucarelli. He simultaneously completed a facial cosmetic surgery fellowship under the preceptorship of Dr. Bradley Lemke. Dr. Kahana’s fellowship thesis won the prestigious Marvin Quickert Award from the American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS). In 2007, Dr. Kahana was recruited to the University of Michigan Kellogg Eye Center, where he rose up the ranks to Associate Professor with Tenure. At the University of Michigan, Dr. Kahana led a research lab studying embryonic development of the eye and orbit, cancer stem cells and inflammation, using a zebrafish model alongside a primary human tissue culture model. A recipient of multiple grants from the National Eye Institute, Institutes of Health, as well as Research to Prevent Blindness and other philanthropic organization, Dr. Kahana has authored over 80 peer-reviewed publications, multiple book chapters and reviews, and has given >100 lectures throughout the United States and internationally, including several endowed lectures and visiting professorships. Dr. Kahana also completed a major prospective clinical trial on the treatment of advanced orbital and periocular basal cell carcinoma. In 2020, Dr. Kahana left the University of Michigan to join the Department of Ophthalmology at Oakland University William Beaumont School of Medicine as Professor. In 2022, Dr. Kahana was named Vice Chair for Academic Affairs in the Department of Ophthalmology. |
Tamer Mahmoud, M.D., Ph.D.Tamer Mahmoud, MD, PhD joined Associated Retinal Consultants/Beaumont hospital in Royal Oak, Michigan in September 2017 and is a professor of Ophthalmology at Oakland University William Beaumont School of Medicine. He moved from North Carolina where he was the program director of the vitreoretinal surgery fellowship at the Duke University Eye center and a tenured associate professor at Duke. He has developed many surgical techniques including the use of subretinal air to displace submacular hemorrhage and developed and performed the first human autologous retinal transplantation. He also introduced chandelier buckles to the United States and developed the ILM retracting door technique for macular holes. In 2019, he developed the Nanovitreoretinal Surgery Platform. Dr. Mahmoud graduated Valedictorian from Ainshams University, finished his internship, residency and vitreoretinal fellowship at the Duke University Eye Center. He is a member of the American Academy of Ophthalmology (AAO), the Association of Research in Vision and Ophthalmology (ARVO), the American Society of Retina Specialists, the Club Jules Gonin, the Macula Society, the Retina Society, and the United States Masters Swimming Association. He is a reviewer for many Ophthalmology journals and a principal investigator on many clinical trials sponsored by the industry and the National Eye Institute. He has been invited as a guest speaker all over the world. Dr. Mahmoud is certified by the American Board of Ophthalmology and is licensed in the states of California, Michigan, and North Carolina. Dr. Mahmoud received the Edward K. Isbey, Jr., M.D. Resident Award for "Excellence in Clinical Care, Ethics, and Research" from the Duke Eye Center, the Retina Research Foundation/"Joseph M. and Eula C. Lawrence" award from ARVO, the "Senior Honor Award" from the American Society of Retina Specialists, The “Achievement Award” from the AAO, the prestigious Robert A. Machemer research award from the Duke Eye Center, the "Distinguished Teacher of the Year Award" from the Kresge Eye Institute and the “Golden Globe Award” for residents’ education from the Duke Eye Center. Dr. Mahmoud is a co-founder of the Arab-African Society of Retina Specialists (AASRS), and founder of the Duke Surgical Rounds Courses launched at national and international conferences in 2013. He served on the national Therapeutic Safety Committee (TSC) for monitoring of drugs and devices, and founded the North Carolina Retina Club (NCRC) in 2012 to allow interaction and collaboration between retina specialists in the state of North Carolina. |
Rajesh Rao, M.D.Dr. Rajesh Rao is a Clinical Professor of Ophthalmology and section Chief of Pediatric Ophthalmology at Oakland University William Beaumont School of Medicine. Dr. Rao completed his medical training at the University of Michigan, followed by residency at Jules Stein Eye Institute/UCLA Medical Center, then fellowship in pediatric ophthalmology and adult strabismus at University of Wisconsin. He has published peer-reviewed articles and book chapters and participates in clinical research projects, including national multi-center trials. He teaches ophthalmology residents from Beaumont Eye Institute, Henry Ford Hospital, and Kresge Eye Institute, and has won the resident teaching award from Beaumont. His clinical interests include the practice of comprehensive pediatric ophthalmology, including conditions such as strabismus, amblyopia, tear duct obstructions and pediatric cataracts. He has a special interest in the management of complex strabismus, including adult strabismus and double vision. He is a member of the American Association of Pediatric Ophthalmology and Strabismus, Michigan Society of Eye Physicians and Surgeons, and the American Academy of Ophthalmology. Dr. Rao and his wife have two children. He enjoys playing tennis and golf, and is an avid football fan and proud University of Michigan alumnus. |
Alan Ruby, M.D.Dr. Ruby received his undergraduate and medical degree with high honors from the University of Michigan. In his residency he served as Chief Resident of the Department of Ophthalmology at Northwestern University. He was a Heed Fellow during his retinal fellowship training at Washington University. Dr. Ruby is currently Clinical Assistant Professor of Biomedical Science at Oakland University. Dr. Ruby has a special interest in diabetic retinopathy and macular degeneration. He is actively involved in a wide array of both basic science and clinical vitreoretinal research studies, and currently serves as principal investigator for multiple NEI studies. Dr. Ruby has been named to The Best Doctors in America is actively involved in fellow and resident education. He is a member of the American Society of Retina Specialists, Retinal Society, The Michigan Society of Eye Physicians & Surgeons, American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, American Medical Association, Michigan State Medical Society, and Oakland County Medical Society, and is a member of the Alpha Omega Alpha Honor Medical Society. |
Kimberly Drenser, M.D., Ph.D.Clinical Associate Professor |
Bruce Garretson, M.D.Clinical Associate Professor |
John Hart, Jr., M.D.Clinical Associate Professor |
George Williams, M.D.Clinical Professor |
Mohamed Al-Shabrawey, MBBCH (M.D.), M.Sc., Ph.D. |
Andrew F.X. Goldberg, Ph.D. |
Kenneth Mitton, Ph.D. |
Michael Risner, Ph.D. |
Amany Tawfik, M.D., M.Sc. |
Dao-Qi Zhang, Ph.D. |
Name | Role |
Kathy Wolosiewicz, M.A. | Operations Coordinator |
Xiao Zhang, M.S. | Al-Shabrawey Lab Manager |
Noureldien Darwish, Ph.D. | Post-Doctoral Fellow, Al-Shabrawey Lab |
Mohamed Moustafa, M.S., Pharm D. | Al-Shabrawey Lab Research Assistant |
Julia Humble, B.S. | Al-Shabrawey Lab Research Associate Technician |
Fatma Awadalla, M.D. | Ph.D. student, Al-Shabrawey Lab |
Youstina Guirguis, MLIS | Lab Volunteer, Al-Shabrawey Lab |
Breyanna Cavanaugh, M.S. | Goldberg Lab Manager |
Michelle Milstein, Ph.D. | Goldberg Lab Research Associate |
Laura Gunther, Ph.D. | Digital Imaging Research Associate |
R. Casey Boucher | Ph.D. Student, Goldberg Lab |
Wendy Dailey B.S. | Pediatric DNA Sequencing, Caeregen Therapeutics Lab Manager |
Naomi Haque | Mitton Lab M.Sc. student, OUWB M2 |
Rima Stepanian | Mitton Lab M2 & EMBARK Student Lab Assistant |
Dylan Heer | Mitton Lab Student Lab Assistant |
Gabrielle Abdelmessih | Mitton Lab Student Research Assistant (SUPER student 2022) |
Cecille Pinnock | Mitton Lab Student Lab Assistant |
Lalith Kumar Venkareddy, Ph.D. | Post-Doctoral Fellow, Tawfik Lab |
Wagdy El-Kalawozg | Tawfik Lab Student Research Volunteer |
Paul Negoita | Tawfik Lab Student Research Volunteer (SUPER student 2022) |
Mohamed Shalaby | Visiting Scholar, Ph.D. Student, Tawfik Lab |
Emilio Romano | Zhang Lab Student Research Assistant (SSCC student 2021) |
Olivia Hannawa | Zhang Lab Student Research Assistant (SSCC student 2021) |
Yasmeen Hassan | Zhang Lab Student Research Assistant (SUPER student 2022) |
Laith Fakhouri | Zhang Lab Volunteer, Summer 2022 |
Andrew Santos | EMBARK Student |
Daeun Jeong | EMBARK Student |
Jonathan Blake | EMBARK Student |
Keaton Schmitz | EMBARK Student |
Konstantinos Koustas | EMBARK Student |
Lance Jones | EMBARK Student |
Mary Drekh | EMBARK Student |
Michael Sun | EMBARK Student |
Min Young Kim | EMBARK Student |
Suhani Gupta | EMBARK Student |
Yunjoo Shin | EMBARK Student |
Amy Perfetto | Administrative Assistant |
Katie Shepherd | OUWB Dean’s Office Assistant |
Annemarie Nguyen | OUWB Director of Business Operations |
In addition to individual investigators' labs, the ERI and OUWB-ERC have a core facility that contains the necessary equipment for morphological, molecular, and functional studies. There are currently four modules and one director for each module:
Microscopy Module: The Ocular Structure and Imaging (OSI) facility is supervised by Andrew Goldberg, Ph.D., and is staffed by a full-time Ph.D. - level digital imaging associate supported by the university. It offers instrumentation and expertise in support of electron and light microscopy studies.
In Vivo Imaging Module: Directed by Amany Tawfik, M.D., M.Sc. This module allows for studying changes in retinal structure and vessels by the fluorescein angiogram and the Optical Coherence Tomogram (OCT). It also allows induction of experimental choroidal neovascularization using laser source (Phoenix Technology Group).
Retinal Function Assessment Module: Directed by Daoqi Zhang, Ph.D., it contains:
- Diagnosys Celeris Electrophysiology System: It provides a full-field dark-adapted and light-adapted electroretinogram (ERG) testing, flash visual evoked potential (VEP) testing, simultaneous ERG and VEP protocol provided, both eyes can be tested individually and automatically, and an anesthesia machine specifically designed to safely deliver isoflurane to mice.
- Cerebral Mechanics OptoMotry-AT System: It provides real-time behavioral testing of optokinetic response for small laboratory animals (rats and mice), spatial frequency and contrast sensitivity testing and manual and automatic trial control and tracking assessment.
- NeurOptics A-2000 Small Animal Pupillometer System: It provides pupillary evaluation in small laboratory animals (rats and mice) in real-time, the binocular dual-camera system measures both eyes at once, four ultra-bright color light stimuli (white, green, blue, and red), and light intensities defined in lux or pure radiometric units (W/m2), stimulates direct, consensual, or both eyes simultaneously and automatic tracking and pupil detection.
Cell and Molecular Biology Module: Directed by Michael Risner, Ph.D., the Cell and Molecular Biology Module provides training and access to Cytation5 Cell Imaging Multimode Reader, Particle-Metrix ZetaView Quatt-NTA Nanoparticle Tracking- Video Microscope and SeahorseXFe96 Analyzer to high-quality live cell analysis. To learn more and book equipment usage, click here.
Pediatric Retinal Research Laboratory (PRRL): The PRRL is directed by Kenneth Mitton, Ph.D. ERI clinical faculty Kimberly Drenser, M.D., Ph.D., and Antonio Capone Jr., M.D., are also associated with the laboratory. It houses a full ocular phenotyping and surgical suite used for characterizing rodent disease models. This includes an additional set of FA/OCT (Bioptigen’s OCT 3). Learn more about the PRRL here.
Date | Details |
Dec. 3, 2024 | Bela Anand-Apte, MBBS, Ph.D., MBA Zoom |
Jan. 17, 2025 | Cameron Prigge, Ph.D., Michigan State University |
Feb. 11, 2025 Kinsey Seminar Series (ERI Conference Room) | Maria Grant, M.D., FARVO, University of Alabama at Birmingham |